Dr. Urano's Blog

​Endoplasmic Reticulum Stress Diseases

The Impact of ER Stress on Human Disease​

Wolfram Syndrome: Diagnosis, Management, and Treatment
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ER Stress and Neurodegenerative Disease

ER Stress and Diabetes

ER Stress and Glucose Homeostasis

WFS-1 Polymorphisms and Type 2 Diabetes

Role of Endoplasmic Reticulum Stress in Metabolic Disease and Other Disorders

Endoplasmic Reticulum Calcium Depletion and Disease

Liraglutide Restores Chronic ER Stress

Wolfram Syndrome

 WFS1 Mutation Frequency 60-fold Higher in Ashkenazi Jewish Individuals - Results in Wolfram Spectrum and Increased Risk for T2DM

Wolfram Syndrome: Diagnosis, Treatment, and Management

Wolfram Syndrome Overview

Wolfram Syndrome Study

 Role of Wolframin Protein

Wolframin and Calcium Homeostasis

Wolframin and SERCA - Molecular Partners

Wolfram Syndrome as a Mitochondriopathy

Treatment For WS

Wolfram Syndrome: Diagnosis, Management, and Treatment

Chemical Chaperones and Treatment of Diabetes and Wolfram Syndrome

Chemical Chaperones in Protein Folding Diseases

MANF for Treatment of WS
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Valproate to Increase WFS-1 Expression

Decreasing Beta-cell Dysfunction in Wolfram Syndrome

AAV Vector Gene Transfer Therapy

AAV Vector  Retinal Target Gene Transfer Therapy

Disease Modifying Treatments for Optic Neuropathies Including Gene Therapy

iPScells for treatment of WS

Preventive Treatment with Liraglutide